how human genetic variations impact pharmacokinetics and pharmacodynamics of drugs and the application for use in the clinical setting. 

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Purpose

The purpose of this assignment is for students to discuss how human genetic variations impact pharmacokinetics and pharmacodynamics of drugs and the application for use in the clinical setting.

Activity Learning Outcomes

Through this discussion, the student will demonstrate the ability to:

1. Explain how pharmacogenomics is currently applied to clinical practice (CO 3,4,5).

2. Discuss the limitations of pharmacogenomics testing (CO 3,4,5).

3. Discuss ethical concerns related to pharmacogenomics testing and treatment (CO 3,4,5).

Requirements:

In your post, respond to the following scenario (Hint: use the pharmgkb website to guide your responses):

1. Before initiating abacavir, an anti-retroviral, for a newly diagnosed HIV positive patient the nurse practitioner orders HLA-B*5701 allele genetic testing. The test confirms that the patient carries the HLA-B*5701 allele.

a. Describe what these results mean.

b. Should the nurse practitioner prescribe abacavir in this case? If not, state why.

2. A patient is prescribed antiplatelet therapy (clopidogrel) following an acute myocardial infarction (MI). Six months later, the patient suffers another acute MI. The patient has been adherent to therapy and the nurse practitioner suspects that clopidrogel may have been ineffective. How might genetic testing have been beneficial in this case?

3. Identify 2 limitations of pharmacogenomics testing. Explain.

4. Identify 2 ethical concerns of using pharmacogenomics testing. Explain.

 

* Textbooks, non-US journals, nursing journals not intended for advanced practice providers or websites intended for the general public are not considered scholarly. 

 

DISCUSSION CONTENT
Category Points % Description
Application of Course Knowledge 35 35% 1. Proper rationale and reasoning skills are demonstrated; AND

2. Information is taken from source(s) with appropriate interpretation/evaluation to develop a comprehensive analysis or synthesis of the topic at hand; AND

3. All of the posts make direct reference to concepts discussed in the lesson; AND

4. Posts are on topic and answer all presented questions which demonstrate a solid understanding of the topic.

(4 critical elements)
Support from Evidence-Based Practice (EBP) 35 35% 1. Discussion posts are supported with appropriate, scholarly sources; uses valid, relevant, and reliable outside sources to contribute to the threaded discussion; AND

2. Sources are published within the last 5 years (unless it is the most current CPG); AND

3. Reference lists are provided and in-text citations match; AND

4. Provides relevant evidence of scholarly inquiry clearly stating how the evidence informed or changed professional or academic decisions.

(4 critical elements)
DISCUSSION FORMAT
Category Points % Description
Grammar, Syntax, Spelling & Punctuation 15 15% Discussion post has minimal grammar, syntax, spelling, punctuation, or APA format errors*

(*) APA style references and in text citations are required; however, there are no deductions for errors in indentation or spacing of references. All elements of the reference otherwise must be included.

 
      Total FORMAT Points= 15 pts
      DISCUSSION TOTAL= 100 pts

Epidemiologic Designs

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Epidemiologic Designs

As introduced in the first few weeks of this course, investigators use various epidemiological study designs to study health problems and the effects of health interventions. You have examined several study designs, including descriptive designs (in Week 2) and analytic study designs that are observational (in Week 3) or experimental (this week). As a DNP student, you should be able to determine which study design would be most suitable for addressing a health problem of interest to you, as this is a foundation for evidence-based practice.

For this Discussion, you will consider which epidemiologic study design (i.e., descriptive, ecologic, cross-sectional, case-control, cohort, or experimental) is most appropriate for investigating the population health problem you selected for Assignment 1. In addition, you will consider which epidemiologic data sources you would use to examine your health problem.

To prepare: Reflect on the population      health problem you identified in Assignment 1, which you will use for      Major Assessment 7, and your early review of the literature. Identify a question for your      study; this will help you select an appropriate design. Consider which epidemiologic      study design (i.e., descriptive, ecologic, cross-sectional, case-control,      cohort, or experimental) is most appropriate for addressing your selected      health problem based upon the assumptions and basic tenets of each design. Determine which      epidemiological design(s) would not be appropriate for your study and why. Also, explore the various      health data resources that were presented in Chapter 5 of the course      text, Epidemiology for Public Health Practice. Consider which      data resources you could use for your study, assessing the strengths and      limitations of those resources.

By tomorrow 03/21//2018, write a minimum of 550 words in APA format with at least 3 scholarly references from the list of required readings below. Include the level one headings as numbered below”

Post a cohesive scholarly response that addresses the following:

1) Briefly summarize the population health problem you selected for Major Assessment 7, and state the study question you want to answer.

2) Explain which epidemiologic study design is most appropriate for your study, as well as the assumptions and tenets that support its application.

3) Analyze the strengths and the limitations of the potential data sources you might use for your study.

Required Readings

Friis, R. H., & Sellers, T. A. (2014). Epidemiology for public health practice (5th ed.). Sudbury, MA: Jones & Bartlett.

Chapter 8, “Experimental Study Designs”

This chapter examines experimental and quasi-experimental study designs.

Johnson, T. S. (2010). A brief review of pharmacotherapeutic treatment options in smoking cessation: Bupropion versus varenicline. Journal of the American Academy of Nurse Practitioners, 22(10), 557–563.

The authors of this article explored treatment options for smoking cessation by examining the research literature, including looking at the results of randomized control trials. This article provides an example of how such a literature review can influence practice demonstrate the use and benefits of randomized control trial study designs.

Milligan, K., Niccols, A., Sword, W., Thabane, L., Henderson, J., Smith, A., & Liu, J. (2010). Maternal substance use and integrated treatment programs for women with substance abuse issues and their children: A meta-analysis. Substance Abuse Treatment, Prevention & Policy, 5, 21–34.

This article examines programs that integrate substance abuse treatment and pregnancy, parenting, or child services. The authors conclude that there is a need for funding of high-quality randomized control trial and improved reporting practices. This article also demonstrates the application of analytic research designs to explore a population health problem.

Talaat, M., Afifi, S., Dueger, E., El-Ashry, N., Marfin, A., Kandeel, A., Mohareb, E., & El-Sayed, N. (2011). Effects of hand hygiene campaigns on incidence of laboratory-confirmed influenza and absenteeism in schoolchildren, Cairo, Egypt. Emerging Infectious Diseases, 17(4), 619–625.

This research study used a randomized control trial to examine the association between hand washing and reducing influenza. As you review this article, notice how they structured the research study and how they measured the association between hand washing and absenteeism.

Physicians’ Health Study (2010). Retrieved from http://phs.bwh.harvard.edu

This large-scale, randomized clinical trial that began in 1982 was designed to test the effectiveness of aspirin and beta carotene in preventing heart attacks (myocardial infarctions, or MIs) in male physicians aged 40–84. The first phase of the trial, which included more than 22,000 study subjects, demonstrated that low-dose aspirin does, in fact, reduce the risk of a first MI by 44%. This article provides a good example of the types of large-scale studies conducted using epidemiologic principles that lead to improved population health.

Required Media

Laureate Education (Producer). (2012). Epidemiology and population health: Experimental studies [Video file]. Baltimore, MD: Author.

Note: The approximate length of this media piece is 5 minutes.

In this program, the presenters discuss experimental studies, including the effect of randomization and blinding on study results.

Optional Resources

Groopman, J. (2006, December 18) Medical dispatch—The right to a trial: Should dying patients have access to experimental drugs? New Yorker, 82(42), 40–47.

Dorak, M. T. (2006). Epidemiologic study designs [PowerPoint presentation]. Retrieved from http://www.dorak.info/epi/design.ppt

Ibrahim, M., Alexander, L., Shy, C., & Farr, S. (2000). Randomized trials. ERIC Notebook, 10, 1–4. Retrieved from

http://cphp.sph.unc.edu/trainingpackages/ERIC/eric_notebook_10.pdf

PICOT STATEMENT AND LITERATURE RESEARCH

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CHECK THE DOCUMENTS ATTACHED BELLOW AS A GUIDE TO COMPLETE THE ASSIGMENT CORRECTLY. .USE THE GRADING RUBRIC TO ANSWER THE ASSIGMENT

 

Details:

The first step of the EBP process is to develop a question from the nursing practice problem of interest.

Select a practice problem of interest to use as the focus of your research.

Start with the patient and identify the clinical problems or issues that arise from clinical care.

Following the PICOT format, write a PICOT statement in your selected practice problem area of interest, which is applicable to your proposed capstone project.

The PICOT statement will provide a framework for your capstone project (the project students must complete during their final course in the RN-BSN program of study).

Conduct a literature search to locate research articles focused on your selected practice problem of interest. This literature search should include both quantitative and qualitative peer-reviewed research articles to support your practice problem.

Select six peer-reviewed research articles which will be utilized through the next 5 weeks as reference sources. Be sure that some of the articles use qualitative research and that some use quantitative research. Create a reference list in which the six articles are listed. Beneath each reference include the article’s abstract. The completed assignment should have a title page and a reference list with abstracts.

Suggestions for locating qualitative and quantitative research articles from credible sources:Use a library database such as CINAHL Complete for your search.Using the advanced search page check the box beside “Research Article” in the “Limit Your Results” section.When setting up the search you can type your topic in the top box, then add quantitative or qualitative as a search term in one of the lower boxes. Research articles often are described as qualitative or quantitative.

To narrow/broaden your search, remove the words qualitative and quantitative and include words that narrow or broaden your main topic. For example: Diabetes and pediatric and dialysis. To determine what research design was used, review the abstract and the methods section of the article. The author will provide a description of data collection using qualitative or quantitative methods.

Prepare this assignment according to the guidelines found in the APA Style Guide, located in the Student Success Center. An abstract is not required.

This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.

 

GRADING RUBRICS

 

 

PICOT Statement and Literature Search

1
Unsatisfactory
0.00%2
Less than Satisfactory
75.00%3
Satisfactory
83.00%4
Good
94.00%5
Excellent
100.00%80.0 %Content  20.0 % Nursing Practice Problem and PICOT Statement A nursing practice problem is not clearly described and/or a PICOT statement is not included.PICOT statement describes a nursing practice problem but lacks reliable sources.PICOT statement describes a nursing practice problem and includes a few reliable sources.PICOT statement articulates a nursing practice problem using supporting information from reliable sources.PICOT statement clearly articulates a nursing practice problem using substantial supporting information from numerous reliable sources.60.0 % Qualitative and Quantitative Research Requirements: At least six references with the abstracts of research studies focus on a selected nursing practice problem. Research articles that address the selected nursing practice problem are not identified.Fewer than six articles that address a selected nursing practice problem are listed in the literature search, but two or more are not research studies. Abstracts are incomplete.Six articles that address a selected nursing practice problem are listed in the literature search, but two are not research studies. Abstracts are partially complete.Six articles that address a selected nursing practice problem are listed in the literature search, but one is not a research study. Abstracts are mostly complete.Six articles that address a selected nursing practice problem are listed in the literature search and include abstracts.10.0 %Organization and Effectiveness  10.0 % Mechanics of Writing (includes spelling, punctuation, grammar, language use) Surface errors are pervasive enough that they impede communication of meaning. Inappropriate word choice or sentence construction is used.Frequent and repetitive mechanical errors distract the reader. Inconsistencies in language choice (register), sentence structure, or word choice are present.Some mechanical errors or typos are present, but they are not overly distracting to the reader. Correct sentence structure and audience-appropriate language are used.Prose is largely free of mechanical errors, although a few may be present. A variety of sentence structures and effective figures of speech are used.Writer is clearly in command of standard, written, academic English.10.0 %Format  10.0 % Documentation of Sources (citations, footnotes, references, bibliography, etc., as appropriate to assignment and style) Sources are not documented.Documentation of sources is inconsistent or incorrect, as appropriate to assignment and style, with numerous formatting errors.Sources are documented, as appropriate to assignment and style, although some formatting errors may be present.Sources are documented, as appropriate to assignment and style, and format is mostly correct.Sources are completely and correctly documented, as appropriate to assignment and style, and format is free of error.100 % Total Weightage

 

 

, Individual Therapies and Nursing Interventions

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Case Study, Mohr

CHAPTER 13, Individual Therapies and Nursing Interventions

In completing the case study, students will be addressing the following learning objective:

Discuss the goals of therapeutic modalities used with individual clients.

1. Frank, a 16-year-old adolescent, is a high school sophomore.  Frank is on the verge of failing his Spanish class.  After his grade fell to a “D” grade, Frank procrastinated about doing his Spanish homework, postponing it until last.  Then, saying he was tired, Frank played video games until bedtime and rationalized that he would get up early in the morning and do his homework. Frank often sleeps late and does not have time to complete his Spanish homework.  Frank is now very distressed over his grade in the Spanish class. His mother brought Frank to the counselor to help with his problem.  The counselor suggested a parent-teacher conference to explore any learning difficulties and the possibility of a tutor to help Frank.  The counselor also said that perhaps Frank’s mother could supervise the completion of his Spanish homework as the first step.  Frank appeared relieved at these suggestions, and said, “That sounds great! Maybe I can improve my Spanish grade and pass the class. Then I won’t be a loser!”

(Learning Objective: 2)

a. Using a cognitive-behavioral approach, write three goals for Frank’s individual counseling sessions.

b. Explain why cognitive-behavioral therapy (CBT) can be successful for Frank.

Future scoope, role, and professional obligation paper

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Advanced registered nursing graduates are entering the profession at dynamic time when roles and scope of practice are shifting based on developments in legislation and policy in response to the evolving needs of the health care system. Professional nursing organizations play an important role in making sure the perspectives of advanced registered nurses are heard, and in supporting nurse specialties in their efforts to expand their scope of practice and their full participation throughout the health care system.

For this assignment, you will conduct research on the current scope of practice for your specialty and efforts that are being made to expand that scope and the role of the advanced nurse in positively influencing the health care system. Write a 1,250-1,500-word paper that includes the following: A discussion of the scope of your future role as an advanced registered nurse, including any regulatory, certification, or accreditation agencies that define that scope. A discussion of three professional nursing organizations that you think are most influential in advancing the scope and influence of advanced nursing. Of these organizations, evaluate the one that you would most like to join. How do its goals and mission fit in with your worldview and philosophy of care? How might membership in this organization improve your practice? A discussion of a controversial or evolving issue that is most likely to affect your scope of practice or role in the next few years. How do you think this issue could influence the profession and other stakeholders, and why does it matters to the advanced registered nurse?

You are required to cite five to 10 sources to complete this assignment. Sources must be published within the last 5 years and appropriate for the assignment criteria and nursing content.

Prepare this assignment according to the guidelines found in the APA Style Guide, located in the Student Success Center. An abstract is not required.

Thesis: California should require all public middle school children to be vaccinated with the HPV shot.

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 You must use this resource multiple times in paper:
Swain, Dharitri, and Swayamprangya Parida. “Preparedness of Young Girls for Prevention of Cervical Cancer and Strategy to Introduce the HPV Vaccine.” Indian Journal of Community Medicine, vol. 43, no. 5, 2018, p. 38., doi:10.4103/ijcm.ijcm_14_18.

Paragraph 1- attention grabber, story etc
Paragraph 2 – Thesis-California should require all public middle school children to be vaccinated with the HPV shot. Background etc.
Next: Best pro argument: Vaccinations not only protect your children, but the entire community from a deadly disease. second people who choose not to vaccinate could create their own school and be segregated. This part would explain what the paper does. explain with fact and studies and cite material. You must introduce why the author was cited who they are and why they are relevant.
The next part is the con part of the paper why people dont agree with the vaccinations. explain in great detail with databases etc. example like religious differences, unnecessary etc. LIke vaccinations cause medical problems. 

Include great transition between pro and con

the last part are the option part like why they should do the vaccine. MY options are like for every family who does the vaccine they get school vouchers for free school supplies and free vouchers for free lunches to increase a healthy diet. Need data and cited material and full explanation why these are important.
conclusion with the best or favorite option which for me is if you agree to the vaccination you will receive free vouchers for your school supplies. can you show this has worked anywhere. 

works cited page need three sources one must be 
Swain, Dharitri, and Swayamprangya Parida. “Preparedness of Young Girls for Prevention of Cervical Cancer and Strategy to Introduce the HPV Vaccine.” Indian Journal of Community Medicine, vol. 43, no. 5, 2018, p. 38., doi:10.4103/ijcm.ijcm_14_18.

must be mla 8 

WK 3 Assignment

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The Assignment:

Examine Case 1. You will be asked to make three decisions concerning the diagnosis and treatment for this client. Be sure to consider co-morbid physical as well as mental factors that might impact the client’s diagnosis and treatment.

At each Decision Point, stop to complete the following: Decision #1: Differential Diagnosis Which Decision did you select? Why did you select this Decision? Support your response with evidence and references to the Learning Resources. What were you hoping to achieve by making this Decision? Support your response with evidence and references to the Learning Resources. Explain any difference between what you expected to achieve with Decision #1 and the results of the Decision. Why were they different? Decision #2: Treatment Plan for Psychotherapy Why did you select this Decision? Support your response with evidence and references to the Learning Resources. What were you hoping to achieve by making this Decision? Support your response with evidence and references to the Learning Resources. Explain any difference between what you expected to achieve with Decision #2 and the results of the Decision. Why were they different? Decision #3: Treatment Plan for Psychopharmacology Why did you select this Decision? Support your response with evidence and references to the Learning Resources. What were you hoping to achieve by making this Decision? Support your response with evidence and references to the Learning Resources. Explain any difference between what you expected to achieve with Decision #3 and the results of the decision. Why were they different? Also include how ethical considerations might impact your treatment plan and communication with clients and their families.  Note: Support your rationale with a minimum of three academic resources. While you may use the course text to support your rationale, it will not count toward the resource requirement. 

CHAPTER 3, Conceptual Frameworks and Theories:

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CHAPTER 3, Conceptual Frameworks and Theories:

In completing the case study, students will be addressing the following learning objective:

Give examples of behavioral and cognitive-behavioral interventions.

The student nurse has been assigned a 37-year-old woman admitted to the psychiatric hospital with an anxiety disorder.  This morning, the student notices that the client has a tense facial expression and is walking constantly around the group room.   The student walked over to the client and used reflective communication by stating, “I see that you have a tense expression and are walking around almost all of the time.  Is there something that we could discuss?”  The client replied that she has talked on the telephone to her mother who was keeping her children while she was in the hospital.  The client said that her mother had told her that she was not a good mother, and then said, “I guess I am a bad mother, but I could never measure up to my mother’s expectations.”  The student has learned that negative self-talk can greatly aggravate anxiety and lead to depression.  The student decided to use a behavioral intervention with the client and asked the client who is a good artist and why the client liked the artist’s works. The student and the client then made a list of activities that the client liked. The student taught the client to engage in one of these activities when an unpleasant experience evoked negative thoughts.  The following day, the student decided that the client needed some cognitive restructuring for her relationship with her mother.  The student taught the client that during discussions with her mother, feelings of incompetence might be experienced when the mother made negative comments.  The client was instructed that if her mother made negative comments about parenting, she was to immediately tell her mother that she was a good parent to her children and terminate the conversation at the first opportunity.

(Learning Objective: 3)

a. Will the client be able to learn cognitive restructuring in her relationship with her mother?

  b.    How will engaging in activities help the client with her anxiety?

Its last minute can u help

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This is a healthcare administration class.

Please no plagiarism no professor checks all papers through many websites

APA format and it has to be two pages one page per scenario can u help me

 

 

In this unit, you will discuss two (2) healthcare issues facing healthcare administrators. In a 2-

page summary, you will identify the bioethical and political issues and discuss how you would 

effectively and ethically handle the situations. You must address both of the following 

scenarios.

Scenario 1: You are the healthcare administrator of a nursing home. You are informed by your 

Admissions Director that a new memory-impaired resident has been admitted into your long-

term care unit. The staff is concerned about the involvement of family with your resident. Family 

members from out-of-town arrived and expressed concern about your resident’s do not 

resuscitate (DNR) orders which were authorized by the Power of Attorney of another family 

member. A quarrel erupts in the nursing home with family members voicing their opinions

loudly. You arrive on the scene and are immediately told by the visiting family member, “Do you 

know who I am? I am a supervisor for the Department of Health and Human Services and will

not hesitate to have your facility surveyed for noncompliance.” What do you do?

Scenario 2: You are the administrator of a for-profit healthcare clinic. The receptionist notifies 

you that a 15-year-old has arrived needing prenatal care and does not want her parents to know 

about her pregnancy. She is covered by her parent’s insurance and does not have enough 

money to privately pay for the visit. What do you do?

Discussion/Assignment

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I seek assistance on 2 separate discussions and 1 assignment